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Generic Flagyl is an all-purpose antiprotozoal and antimicrobial drug. Being a Nitroimidazole derivative this medication contains an active ingredient Metronidazole known as its brand name under which it is sold. The mode of action is based on the reduction of the 5-nitro group by proteins of intracellular protozoan parasites.
The activated Metronidazole 5-nitro group interacts directly with pathogenic bacteria, suppressing the nucleic acids synthesis which causes disease-producing germs to die. The main metabolite is 2-oxymetronidazole that exhibits antimicrobial and antiprotozoal activities.
Flagyl is meant to treat genital diseases and other infections that affect both adults and children. It is worth emphasizing that the agent has proven to be ineffective in killing facultative anaerobic microorganisms.
No one should take Flagyl without consulting a medical care provider. This means that the patient must not receive Metronidasole treatment without prescription. Only doctor can pick the right dose for each ill person to ensure maximum benefits from the drug and mitigate side effects of the therapy.
Taken by mouth, Flagyl is quickly and almost fully absorbed into the bloodstream, lungs, skin and tissues. Meal does not prevent the medicament from entering the body. The drug has a bioavailability of 100%. The most part of Metronidazole exits the human organism primarily through the kidneys while the half-life is about 10 hours.
Generic Flagyl is commonly prescribed to treat the following medical conditions or diseases:
- Protozoal infections (trichomoniasis, amoebic dysentery, etc.)
- Infectious diseases of the nervous system
- Pneumonia, sepsis, lung abscess
- Genitourinary infections
- Infectious diseases of the abdominal cavity
- Pseudomembranous colitis that occurs in the presence of antibiotic therapy
- Gastritis and duodenal ulcers caused by Helicobacter pylori
In addition, Generic Flagyl is used as a precaution after surgery, in gynecology and other areas of medicine.
Contraindications and precautionary measures
Metronidazole should not be administered in such cases:
- Serious nervous damage
- Renal insufficiency
- Blood disorders
- Allergic reaction the drug
- Children under 10 years
Moreover, special care should be taken when prescribing Flagyl for patients with renal encephalopathy, chronic central nervous system disorders, kidney diseases.
The drug should not be combined with alcohol in order to avoid vomiting, palpitations, convulsions, etc.
Trichomoniasis infection is cured in both intimate partners simultaneously to kill the parasite. Also, during the therapy, doctors recommend abstaining from sex completely. Menstruating women must avoid taking the medicament.
If a patient uses the preparation over a long period of time he or she may develop side effects, therefore the treatment should be carried out under the strict supervision of a doctor.
Other drug interactions
There is the need to limit the intake of ethanol-containing medications, since Flagyl is known to cause intolerance to ethanol.
The recommended dose should not be exceeded otherwise it may lead to vomiting, impaired coordination, ataxia. If these still occur it is necessary to immediately stop taking the remedy and initiate standard measures that are used to cure an intoxicated person.
The drug must be stored in a dry place inaccessible to children, at a temperature not exceeding 25 degrees Celsius. Shelf life is 4 years.